The Chiltern Hundreds may refer to:
- Chiltern Hundreds, an ancient administrative area in Buckinghamshire, England
- Crown Steward and Bailiff of the Chiltern Hundreds, a position used as a procedural device to allow resignation from the House of Commons
- The Chiltern Hundreds (play), a 1947 play
- The Chiltern Hundreds (film), a 1949 film adaptation of the play