Tight junction protein ZO-2 is a protein that in humans is encoded by the TJP2 gene .[5]
Tight junction proteins (TJPs) belong to a family of membrane-associated guanylate kinase (MAGUK) homologs that are involved in the organization of epithelial and endothelial intercellular junctions. TJPs bind to the cytoplasmic C termini of junctional transmembrane proteins and link them to the actin cytoskeleton [supplied by OMIM].[6]
Interactions
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References
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^ a b c GRCh38: Ensembl release 89: ENSG00000119139 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024812 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Duclos F, Rodius F, Wrogemann K, Mandel JL, Koenig M (November 1994). "The Friedreich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb". Hum Mol Genet . 3 (6): 909–914. doi :10.1093/hmg/3.6.909 . PMID 7951235 .
^ "Entrez Gene: TJP2 tight junction protein 2 (zona occludens 2)" .
^ a b Itoh, M; Morita K; Tsukita S (February 1999). "Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin" . J. Biol. Chem . 274 (9): 5981–5986. doi :10.1074/jbc.274.9.5981 . ISSN 0021-9258 . PMID 10026224 .
^ a b Wittchen, E S; Haskins J; Stevenson B R (December 1999). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3" . J. Biol. Chem . 274 (49): 35179–35185. doi :10.1074/jbc.274.49.35179 . ISSN 0021-9258 . PMID 10575001 .
^ Fanning, A S; Jameson B J; Jesaitis L A; Anderson J M (November 1998). "The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton" . J. Biol. Chem . 273 (45): 29745–29753. doi :10.1074/jbc.273.45.29745 . ISSN 0021-9258 . PMID 9792688 .
^ Mattagajasingh, S N; Huang S C; Hartenstein J S; Benz E J (September 2000). "Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton" . J. Biol. Chem . 275 (39): 30573–30585. doi :10.1074/jbc.M004578200 . ISSN 0021-9258 . PMID 10874042 .
^ Peng, Bi-Hung; Lee J Ching; Campbell Gerald A (December 2003). "In vitro protein complex formation with cytoskeleton-anchoring domain of occludin identified by limited proteolysis" . J. Biol. Chem . 278 (49): 49644–49651. doi :10.1074/jbc.M302782200 . ISSN 0021-9258 . PMID 14512431 .
^ Kazmierczak M, Harris SL, Kazmierczak P, Shah P, Starovoytov V, Ohlemiller KK, Schwander M (November 2015). "Progressive Hearing Loss in Mice Carrying a Mutation in Usp53" . The Journal of Neuroscience . 35 (47): 15582–98. doi :10.1523/JNEUROSCI.1965-15.2015 . PMC 4659823 . PMID 26609154 .
Further reading
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Denker BM, Nigam SK (1998). "Molecular structure and assembly of the tight junction". Am. J. Physiol . 274 (1 Pt 2): F1–9. doi :10.1152/ajprenal.1998.274.1.F1 . PMID 9458817 .
González-Mariscal L, Betanzos A, Avila-Flores A (2000). "MAGUK proteins: structure and role in the tight junction". Semin. Cell Dev. Biol . 11 (4): 315–324. doi :10.1006/scdb.2000.0178 . PMID 10966866 .
King JE, Eugenin EA, Buckner CM, Berman JW (2006). "HIV tat and neurotoxicity" . Microbes Infect . 8 (5): 1347–1357. doi :10.1016/j.micinf.2005.11.014 . PMID 16697675 .
Van Itallie CM, Balda MS, Anderson JM (1995). "Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells". J. Cell Sci . 108 (4): 1735–42. doi :10.1242/jcs.108.4.1735 . PMID 7542259 .
Beatch M, Jesaitis LA, Gallin WJ, et al. (1996). "The tight junction protein ZO-2 contains three PDZ (PSD-95/Discs-Large/ZO-1) domains and an alternatively spliced region" . J. Biol. Chem . 271 (42): 25723–25726. doi :10.1074/jbc.271.42.25723 . PMID 8824195 .
Itoh M, Morita K, Tsukita S (1999). "Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin" . J. Biol. Chem . 274 (9): 5981–5986. doi :10.1074/jbc.274.9.5981 . PMID 10026224 .
Chlenski A, Ketels KV, Tsao MS, et al. (1999). "Tight junction protein ZO-2 is differentially expressed in normal pancreatic ducts compared to human pancreatic adenocarcinoma". Int. J. Cancer . 82 (1): 137–144. doi :10.1002/(SICI)1097-0215(19990702)82:1<137::AID-IJC23>3.0.CO;2-F . PMID 10360833 . S2CID 11349543 .
Chlenski A, Ketels KV, Engeriser JL, et al. (1999). "zo-2 gene alternative promoters in normal and neoplastic human pancreatic duct cells" . Int. J. Cancer . 83 (3): 349–358. doi :10.1002/(SICI)1097-0215(19991029)83:3<349::AID-IJC10>3.0.CO;2-C . PMID 10495427 .
Wittchen ES, Haskins J, Stevenson BR (2000). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3" . J. Biol. Chem . 274 (49): 35179–35185. doi :10.1074/jbc.274.49.35179 . PMID 10575001 .
Itoh M, Furuse M, Morita K, et al. (2000). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins" . J. Cell Biol . 147 (6): 1351–1363. doi :10.1083/jcb.147.6.1351 . PMC 2168087 . PMID 10601346 .
Cordenonsi M, D'Atri F, Hammar E, et al. (2000). "Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin" . J. Cell Biol . 147 (7): 1569–1582. doi :10.1083/jcb.147.7.1569 . PMC 2174252 . PMID 10613913 .
Mattagajasingh SN, Huang SC, Hartenstein JS, Benz EJ (2000). "Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton" . J. Biol. Chem . 275 (39): 30573–30585. doi :10.1074/jbc.M004578200 . PMID 10874042 .
Chlenski A, Ketels KV, Korovaitseva GI, et al. (2000). "Organization and expression of the human zo-2 gene (tjp-2) in normal and neoplastic tissues". Biochim. Biophys. Acta . 1493 (3): 319–24. doi :10.1016/S0167-4781(00)00185-8 . PMID 11018256 .
Citi S, D'Atri F, Parry DA (2000). "Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly". J. Struct. Biol . 131 (2): 135–145. doi :10.1006/jsbi.2000.4284 . PMID 11042084 .
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788–1795. doi :10.1101/gr.143000 . PMC 310948 . PMID 11076863 .
Glaunsinger BA, Weiss RS, Lee SS, Javier R (2001). "Link of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2" . EMBO J . 20 (20): 5578–5586. doi :10.1093/emboj/20.20.5578 . PMC 125668 . PMID 11598001 .
Islas S, Vega J, Ponce L, González-Mariscal L (2002). "Nuclear localization of the tight junction protein ZO-2 in epithelial cells". Exp. Cell Res . 274 (1): 138–148. doi :10.1006/excr.2001.5457 . PMID 11855865 .