Protein kinase C and casein kinase substrate in neurons protein 1 also known as syndapin I[5][6] is an enzyme that in humans is encoded by the PACSIN1 gene.[7]

PACSIN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPACSIN1, SDPI, protein kinase C and casein kinase substrate in neurons 1
External IDsOMIM: 606512; MGI: 1345181; HomoloGene: 22674; GeneCards: PACSIN1; OMA:PACSIN1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001199583
NM_020804

NM_001286743
NM_001286744
NM_011861
NM_178365

RefSeq (protein)

NP_001186512
NP_065855

NP_001273672
NP_001273673
NP_035991
NP_848142

Location (UCSC)Chr 6: 34.47 – 34.54 MbChr 17: 27.87 – 27.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

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PACSIN1 has been shown to interact with GTPases of the Dynamin family (Dynamin 1, 2 and 3). Based on this interaction, its localization and functional role the protein was named syndapin I (synaptic dynamin-associated protein I).

A variety of interactions have been published:

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124507Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040276Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "PACSIN1 protein kinase C and casein kinase substrate in neurons 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-08-04.
  6. ^ "Pacsin1 protein kinase C and casein kinase substrate in neurons 1 [Mus musculus (house mouse)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-08-04.
  7. ^ Sumoy L, Pluvinet R, Andreu N, Estivill X, Escarceller M (Jan 2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family". Gene. 262 (1–2): 199–205. doi:10.1016/S0378-1119(00)00531-X. PMID 11179684.
  8. ^ Qualmann B, Roos J, DiGregorio PJ, Kelly RB (February 1999). Pfeffer SR (ed.). "Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein". Molecular Biology of the Cell. 10 (2): 501–513. doi:10.1091/mbc.10.2.501. PMC 25183. PMID 9950691.
  9. ^ Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, et al. (Sep 2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis". The Journal of Biological Chemistry. 279 (38): 40091–9. doi:10.1074/jbc.M404899200. PMID 15252009.
  10. ^ a b c Modregger J, Ritter B, Witter B, Paulsson M, Plomann M (Dec 2000). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". Journal of Cell Science. 113 (24): 4511–21. doi:10.1242/jcs.113.24.4511. PMID 11082044.
  11. ^ Modregger J, DiProspero NA, Charles V, Tagle DA, Plomann M (Oct 2002). "PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains". Human Molecular Genetics. 11 (21): 2547–58. doi:10.1093/hmg/11.21.2547. PMID 12354780.
  12. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

Further reading

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  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1)