Zinc transporter 4

Zinc transporter 4 is a protein that in humans is encoded by the SLC30A4 gene.

SLC30A4
Identifiers
Aliases	SLC30A4, ZNT4, znT-4, solute carrier family 30 member 4
External IDs	OMIM: 602095; MGI: 1345282; HomoloGene: 74984; GeneCards: SLC30A4; OMA:SLC30A4 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q21.1|15q21.1 Start 45,479,606 bp End 45,522,755 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 E5|2 60.65 cM Start 122,523,153 bp End 122,544,583 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa Brodmann area 23 middle temporal gyrus oocyte secondary oocyte germinal epithelium endothelial cell external globus pallidus synovial joint gingival epithelium Top expressed in jejunum ileum uterus placenta spermatid secondary oocyte genital tubercle Cortex of frontal lobe testicle colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cation transmembrane transporter activity zinc ion transmembrane transporter activity protein binding Cellular component cytoplasm integral component of membrane endosome late endosome membrane late endosome membrane lysosomal membrane lysosome endosome membrane plasma membrane Biological process zinc ion homeostasis zinc ion transport response to zinc ion cation transport ion transport cation transmembrane transport transmembrane transport regulation of sequestering of zinc ion response to toxic substance zinc ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7782 22785 Ensembl ENSG00000104154 ENSMUSG00000005802 UniProt O14863 O35149 RefSeq (mRNA) NM_013309 NM_001321036 NM_001290993 NM_011774 RefSeq (protein) NP_001307965 NP_037441 NP_001277922 NP_035904 Location (UCSC) Chr 15: 45.48 – 45.52 Mb Chr 2: 122.52 – 122.54 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

Further reading

• Huang L, Gitschier J (1997). "A novel gene involved in zinc transport is deficient in the lethal milk mouse". Nat. Genet. 17 (3): 292–7. doi:10.1038/ng1197-292. PMID 9354792. S2CID 8000689.
• Murgia C, Vespignani I, Cerase J, et al. (2000). "Cloning, expression, and vesicular localization of zinc transporter Dri 27/ZnT4 in intestinal tissue and cells". Am. J. Physiol. 277 (6 Pt 1): G1231–9. doi:10.1152/ajpgi.1999.277.6.G1231. PMID 10600821. S2CID 31257828.
• Küry S, Devilder MC, Avet-Loiseau H, et al. (2001). "Expression pattern, genomic structure and evaluation of the human SLC30A4 gene as a candidate for acrodermatitis enteropathica". Hum. Genet. 109 (2): 178–85. doi:10.1007/s004390100539. PMID 11511923. S2CID 11501283.
• Bleck O, Ashton GH, Mallipeddi R, et al. (2002). "Genomic localization, organization and amplification of the human zinc transporter protein gene, ZNT4, and exclusion as a candidate gene in different clinical variants of acrodermatitis enteropathica". Arch. Dermatol. Res. 293 (8): 392–6. doi:10.1007/s004030100246. PMID 11686514. S2CID 13027648.
• Nakano A, Nakano H, Hanada K, et al. (2002). "ZNT4 gene is not responsible for acrodermatitis enteropathica in Japanese families". Hum. Genet. 110 (2): 201–2. doi:10.1007/s00439-001-0661-7. PMID 11935329. S2CID 37006354.
• Michalczyk AA, Allen J, Blomeley RC, Ackland ML (2002). "Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells". Biochem. J. 364 (Pt 1): 105–13. doi:10.1042/bj3640105. PMC 1222551. PMID 11988082.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Michalczyk A, Varigos G, Catto-Smith A, et al. (2003). "Analysis of zinc transporter, hZnT4 ( Slc30A4), gene expression in a mammary gland disorder leading to reduced zinc secretion into milk". Hum. Genet. 113 (3): 202–10. doi:10.1007/s00439-003-0952-2. PMID 12743795. S2CID 36141272.
• Henshall SM, Afar DE, Rasiah KK, et al. (2003). "Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer". Oncogene. 22 (38): 6005–12. doi:10.1038/sj.onc.1206797. PMID 12955079.
• Beck FW, Prasad AS, Butler CE, et al. (2004). "Differential expression of hZnT-4 in human prostate tissues". Prostate. 58 (4): 374–81. doi:10.1002/pros.10344. PMID 14968438. S2CID 24889031.
• Ho LH, Ruffin RE, Murgia C, et al. (2004). "Labile zinc and zinc transporter ZnT4 in mast cell granules: role in regulation of caspase activation and NF-kappaB translocation". J. Immunol. 172 (12): 7750–60. doi:10.4049/jimmunol.172.12.7750. PMID 15187159.
• Smith JL, Xiong S, Markesbery WR, Lovell MA (2006). "Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain". Neuroscience. 140 (3): 879–88. doi:10.1016/j.neuroscience.2006.02.049. PMID 16580781. S2CID 29807730.