SCO-spondin is a protein that in humans is encoded by the SSPO gene.[5][6][7] SCO-spondin is secreted by the subcommissural organ, and contributes to commissural axon growth and the formation of Reissner's fiber, a fibrous aggregation of secreted molecules extending from the subcommissural organ to the end of the spinal cord.[8]

SSPOP
Identifiers
AliasesSSPOP, SCO-spondin, SCO-spondin, pseudogene, SSPO
External IDsOMIM: 617356 MGI: 2674311 HomoloGene: 45453 GeneCards: SSPOP
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198455

NM_173428

RefSeq (protein)

NP_940857

NP_775604

Location (UCSC)Chr 7: 149.78 – 149.83 MbChr 6: 48.43 – 48.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197558 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029797 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gobron S, Monnerie H, Meiniel R, Creveaux I, Lehmann W, Lamalle D, Dastugue B, Meiniel A (May 1996). "SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation". Journal of Cell Science. 109. 109 ( Pt 5) (5): 1053–61. doi:10.1242/jcs.109.5.1053. PMID 8743952.
  6. ^ Gobron S, Creveaux I, Meiniel R, Didier R, Herbet A, Bamdad M, El Bitar F, Dastugue B, Meiniel A (November 2000). "Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth". Glia. 32 (2): 177–91. doi:10.1002/1098-1136(200011)32:2<177::AID-GLIA70>3.0.CO;2-V. PMID 11008217. S2CID 46625717.
  7. ^ "Entrez Gene: SSPO SCO-spondin homolog (Bos taurus)".
  8. ^ Gobron S, Creveaux I, Meiniel R, Didier R, Dastugue B, Meiniel A (January 1999). "SCO-spondin is evolutionarily conserved in the central nervous system of the chordate phylum". Neuroscience. 88 (2): 655–64. doi:10.1016/s0306-4522(98)00252-8. PMID 10197783. S2CID 426154.

Further reading edit