60S ribosomal protein L37

60S ribosomal protein L37 is a protein that in humans is encoded by the RPL37 gene.

RPL37
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 4D67, 4UJC, 4D5Y, 4UJE, 4UJD, 4V5Z
Identifiers
Aliases	RPL37, L37, ribosomal protein L37
External IDs	OMIM: 604181; MGI: 1914531; HomoloGene: 68110; GeneCards: RPL37; OMA:RPL37 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5p13.1 Start 40,825,262 bp End 40,835,222 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 A1 Start 5,146,127 bp End 5,148,622 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium nipple urethra human penis parietal pleura pylorus palpebral conjunctiva caput epididymis mucosa of sigmoid colon visceral pleura Top expressed in embryo embryo lip ventricular zone dentate gyrus of hippocampal formation granule cell yolk sac primary visual cortex superior frontal gyrus granulocyte muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding rRNA binding structural constituent of ribosome RNA binding Cellular component ribosome cytosol intracellular anatomical structure cytosolic large ribosomal subunit synapse Biological process SRP-dependent cotranslational protein targeting to membrane viral transcription nuclear-transcribed mRNA catabolic process, nonsense-mediated decay translational initiation protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6167 67281 Ensembl ENSG00000145592 ENSMUSG00000041841 UniProt P61927 Q9D823 RefSeq (mRNA) NM_000997 NM_026069 RefSeq (protein) NP_000988 NP_080345 Location (UCSC) Chr 5: 40.83 – 40.84 Mb Chr 15: 5.15 – 5.15 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C2C2-type zinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Su S, Bird RC (1995). "Cell cycle, differentiation and tissue-independent expression of ribosomal protein L37". Eur. J. Biochem. 232 (3): 789–97. doi:10.1111/j.1432-1033.1995.tb20874.x. PMID 7588717.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Schwartz EI, Intine RV, Maraia RJ (2004). "CK2 Is Responsible for Phosphorylation of Human La Protein Serine-366 and Can Modulate rpL37 5′-Terminal Oligopyrimidine mRNA Metabolism". Mol. Cell. Biol. 24 (21): 9580–91. doi:10.1128/MCB.24.21.9580-9591.2004. PMC 522270. PMID 15485924.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• Overview of all the structural information available in the PDB for UniProt: P61927 (Human 60S ribosomal protein L37) at the PDBe-KB.