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Persico is an Italian surname, which means Persian as in "Golfo Persico" (Italian for Persian Gulf). Notable people with the surname include:
- Aaron Persico, Italian rugby player
- Alphonse Persico, American mobster nicknamed "Allie Boy"
- Carmine Persico, American mobster
- Daniel Pérsico, politician
- Enrico Persico, Italian physicist
- Ignatius Persico, Italian Cardinal
- Joseph E. Persico, author
- Lawrence T. Persico, Bishop of Erie, Pennsylvania
- Salvatore Persico, birth name of baseball catcher Joe Smith
- Silvia Persico, Italian cyclist