Pou class 3 homeobox 3

POU class 3 homeobox 3 is a protein that in humans is encoded by the POU3F3 gene.

POU3F3
Identifiers
Aliases	POU3F3, BRN1, OTF8, brain-1, oct-8, POU class 3 homeobox 3, SNIBFIS
External IDs	OMIM: 602480 MGI: 102564 HomoloGene: 68509 GeneCards: POU3F3
Gene location (Human) Chr. Chromosome 2 (human) Band 2q12.1 Start 104,853,287 bp End 104,858,574 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 B|1 21.21 cM Start 42,734,085 bp End 42,742,336 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence corpus epididymis renal medulla seminal vesicula internal globus pallidus caput epididymis inferior ganglion of vagus nerve postcentral gyrus external globus pallidus subthalamic nucleus Top expressed in medial ganglionic eminence globus pallidus medullary collecting duct dorsal tegmental nucleus lower lip ventral tegmental area dorsomedial hypothalamic nucleus maxillary prominence nucleus accumbens subiculum More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity HMG box domain binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated kidney development regulation of transcription by RNA polymerase II negative regulation of apoptotic process transcription, DNA-templated nervous system development metanephric ascending thin limb development positive regulation of transcription, DNA-templated multicellular organism development central nervous system development forebrain ventricular zone progenitor cell division brain development positive regulation of gene expression metanephric loop of Henle development positive regulation of cell population proliferation negative regulation of transcription, DNA-templated cerebral cortex radially oriented cell migration metanephric thick ascending limb development positive regulation of transcription by RNA polymerase II metanephric DCT cell differentiation metanephric macula densa development excretion chemical homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5455 18993 Ensembl ENSG00000198914 ENSMUSG00000045515 UniProt P20264 P31361 RefSeq (mRNA) NM_006236 NM_008900 RefSeq (protein) NP_006227 NP_032926 Location (UCSC) Chr 2: 104.85 – 104.86 Mb Chr 1: 42.73 – 42.74 Mb PubMed search
Wikidata
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Function

This gene encodes a POU-domain containing protein that functions as a transcription factor. The encoded protein recognizes an octamer sequence in the DNA of target genes. This protein may play a role in development of the nervous system. [provided by RefSeq, Apr 2015].

Further reading

• Li W, Zheng J, Deng J, You Y, Wu H, Li N, Lu J, Zhou Y (June 2014). "Increased levels of the long intergenic non-protein coding RNA POU3F3 promote DNA methylation in esophageal squamous cell carcinoma cells". Gastroenterology. 146 (7): 1714–26.e5. doi:10.1053/j.gastro.2014.03.002. PMID 24631494.
• Guo H, Wu L, Yang Q, Ye M, Zhu X (January 2015). "Functional linc-POU3F3 is overexpressed and contributes to tumorigenesis in glioma". Gene. 554 (1): 114–9. doi:10.1016/j.gene.2014.10.038. PMID 25445282.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.