MAS1

MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor (MRGA, MAS, MGRA""), is a protein that in humans is encoded by the MAS1 gene. The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.

MAS1
Identifiers
Aliases	MAS1, MAS1 proto-oncogene, G protein-coupled receptor, MAS, MGRA
External IDs	OMIM: 165180; MGI: 96918; HomoloGene: 1782; GeneCards: MAS1; OMA:MAS1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q25.3 Start 159,890,988 bp End 159,917,447 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 A1|17 8.69 cM Start 13,059,966 bp End 13,087,030 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle prefrontal cortex Brodmann area 9 right frontal lobe anterior cingulate cortex primary visual cortex hippocampus proper gonad amygdala lymph node Top expressed in dentate gyrus of hippocampal formation granule cell spermatid CA3 field entorhinal cortex perirhinal cortex Ileal epithelium yolk sac primary visual cortex superior frontal gyrus seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity angiotensin type II receptor activity peptide binding signal transducer activity peptide hormone binding angiotensin receptor activity protein binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane cell surface intracellular anatomical structure Biological process negative regulation of protein phosphorylation G protein-coupled receptor signaling pathway male gonad development positive regulation of inositol phosphate biosynthetic process angiotensin-activated signaling pathway anatomical structure morphogenesis response to peptide hormone activation of NF-kappaB-inducing kinase activity protein kinase C signaling response to activity response to gonadotropin positive regulation of DNA replication cellular response to peptide hormone stimulus spermatogenesis positive regulation of cell population proliferation regulation of inflammatory response cell population proliferation hippocampus development signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4142 17171 Ensembl ENSG00000130368 ENSMUSG00000068037 UniProt P04201 P30554 RefSeq (mRNA) NM_002377 NM_001366704 NM_008552 RefSeq (protein) NP_002368 NP_001353633 NP_032578 Location (UCSC) Chr 6: 159.89 – 159.92 Mb Chr 17: 13.06 – 13.09 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Agonists of the receptor include angiotensin-(1-7). Antagonist include A-779 (angiotensin-1-7 with c-terminal proline substituted for D-Ala), or D-Pro (angiotensin-1-7 with c-terminal proline submitted for D-proline).

Mas1 proto-oncogene (MAS1, MGRA) is not to be confused with the MAS-related G-protein coupled receptor, a recently believed to be activated by the ligand alamandine (generated by catalysis of Ang A via ACE2 or directly from Ang-(1-7)).

See also

• MAS1 oncogene

Further reading

• Hanley MR (1992). "Molecular and cell biology of angiotensin receptors". Journal of Cardiovascular Pharmacology. 18 (Suppl 2): S7-13. doi:10.1097/00005344-199106182-00003. PMID 1725048.
• Hanley MR, Cheung WT, Hawkins P, Poyner D, Benton HP, Blair L, Jackson TR, Goedert M (1990). "The mas Oncogene as a Neural Peptide Receptor: Expression, Regulation and Mechanism of Action". Ciba Foundation Symposium 150 - Proto-Oncogenes in Cell Development. Novartis Foundation Symposia. Vol. 150. pp. 23–38, discussion 38–46. doi:10.1002/9780470513927.ch3. ISBN 978-0-470-51392-7. PMID 2197067.
• Rabin M, Birnbaum D, Young D, Birchmeier C, Wigler M, Ruddle FH (Jul 1987). "Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements". Oncogene Research. 1 (2): 169–78. PMID 3329713.
• Jackson TR, Blair LA, Marshall J, Goedert M, Hanley MR (Sep 1988). "The mas oncogene encodes an angiotensin receptor". Nature. 335 (6189): 437–40. Bibcode:1988Natur.335..437J. doi:10.1038/335437a0. PMID 3419518. S2CID 4360847.
• Young D, Waitches G, Birchmeier C, Fasano O, Wigler M (Jun 1986). "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains". Cell. 45 (5): 711–9. doi:10.1016/0092-8674(86)90785-3. PMID 3708691. S2CID 29886272.
• Riesewijk AM, Schepens MT, Mariman EM, Ropers HH, Kalscheuer VM (Jul 1996). "The MAS proto-oncogene is not imprinted in humans". Genomics. 35 (2): 380–2. doi:10.1006/geno.1996.0372. PMID 8661154.
• Xu X, Quiambao AB, Roveri L, Pardue MT, Marx JL, Röhlich P, Peachey NS, Al-Ubaidi MR (May 2000). "Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene". Experimental Neurology. 163 (1): 207–19. doi:10.1006/exnr.2000.7370. PMID 10785460. S2CID 24445328.
• Alenina N, Baranova T, Smirnow E, Bader M, Lippoldt A, Patkin E, Walther T (May 2002). "Cell type-specific expression of the Mas proto-oncogene in testis". The Journal of Histochemistry and Cytochemistry. 50 (5): 691–6. doi:10.1177/002215540205000510. PMID 11967280. S2CID 44690751.
• Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T (Jul 2003). "Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas". Proceedings of the National Academy of Sciences of the United States of America. 100 (14): 8258–63. Bibcode:2003PNAS..100.8258S. doi:10.1073/pnas.1432869100. PMC 166216. PMID 12829792.
• Canals M, Jenkins L, Kellett E, Milligan G (Jun 2006). "Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS". The Journal of Biological Chemistry. 281 (24): 16757–67. doi:10.1074/jbc.M601121200. PMID 16611642.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.