Ōtani, Otani or Ohtani may refer to:
- Ōtani (surname), a Japanese surname
- Ōtani University, a private Buddhist university in Kita-ku, Kyoto, Japan
- Ōtani-ha, a branch of the Jōdo Shinshū school of Pure Land Buddhism
- The House of Ōtani, family of the descendants of Shinran, founder of Jōdo Shinshū