OPG may refer to:
- Osteoprotegerin
- Office of the Public Guardian (disambiguation)
- Office of HM Paymaster General
- Online Policy Group
- Ontario Power Generation
- Open Government Partnership
- Optical parametric generator
- Orthopantomograph, a panoramic radiograph
- Orthopantogram or Panoramic radiograph
This disambiguation page lists articles associated with the title OPG.
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