NEUROD2

Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.

NEUROD2
Identifiers
Aliases	NEUROD2, NDRF, bHLHa1, neuronal differentiation 2, EIEE72, DEE72
External IDs	OMIM: 601725; MGI: 107755; HomoloGene: 4489; GeneCards: NEUROD2; OMA:NEUROD2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q12 Start 39,603,536 bp End 39,609,777 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 D|11 61.75 cM Start 98,216,241 bp End 98,220,474 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence right hemisphere of cerebellum right frontal lobe cingulate gyrus anterior cingulate cortex Brodmann area 9 paraflocculus of cerebellum hippocampus proper prefrontal cortex superior frontal gyrus Top expressed in CA3 field primary visual cortex perirhinal cortex entorhinal cortex dentate gyrus of hippocampal formation granule cell cerebellar cortex ventricular zone superior frontal gyrus Region I of hippocampus proper hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein dimerization activity transcription corepressor activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific E-box binding protein heterodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process cellular response to calcium ion regulation of neuron differentiation cell differentiation negative regulation of nucleic acid-templated transcription positive regulation of calcium-mediated signaling associative learning regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II positive regulation of DNA-binding transcription factor activity neuron development transcription by RNA polymerase II behavioral fear response transcription, DNA-templated nervous system development positive regulation of synaptic plasticity negative regulation of synapse maturation multicellular organism development positive regulation of synapse maturation protein ubiquitination positive regulation of neuron differentiation cerebellar cortex development regulation of synapse maturation positive regulation of transcription by RNA polymerase II cellular response to electrical stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4761 18013 Ensembl ENSG00000171532 ENSMUSG00000038255 UniProt Q15784 Q62414 RefSeq (mRNA) NM_006160 NM_010895 RefSeq (protein) NP_006151 NP_035025 Location (UCSC) Chr 17: 39.6 – 39.61 Mb Chr 11: 98.22 – 98.22 Mb PubMed search
Wikidata
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Function

This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.

Interactions

NEUROD2 has been shown to interact with Protein kinase N1.

Further reading

• McCormick MB, Tamimi RM, Snider L, Asakura A, Bergstrom D, Tapscott SJ (Oct 1996). "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family". Molecular and Cellular Biology. 16 (10): 5792–800. doi:10.1128/mcb.16.10.5792. PMC 231580. PMID 8816493.
• Kume H, Maruyama K, Shinozaki K, Kuzume H, Obata K (Sep 1998). "Phosphorylation and spatiotemporal distribution of KW8 (NDRF/NeuroD2), a NeuroD family basic helix-loop-helix protein". Brain Research. Molecular Brain Research. 60 (1): 107–14. doi:10.1016/S0169-328X(98)00176-4. PMID 9748526.
• Kitamura T, Miyachi T, Nakamura S, Kawakami H (Apr 1999). "Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF)1". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1445 (1): 142–7. doi:10.1016/s0167-4781(99)00038-x. PMID 10209266.
• Shibata H, Oda H, Mukai H, Oishi K, Misaki K, Ohkubo H, Ono Y (Dec 1999). "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Research. Molecular Brain Research. 74 (1–2): 126–34. doi:10.1016/S0169-328X(99)00273-9. PMID 10640683.
• Cousin P, Billotte J, Chaubert P, Shaw P (Jan 2000). "Physical map of 17p13 and the genes adjacent to p53". Genomics. 63 (1): 60–8. doi:10.1006/geno.1999.6062. PMID 10662545.
• Franklin A, Kao A, Tapscott S, Unis A (Nov 2001). "NeuroD homologue expression during cortical development in the human brain". Journal of Child Neurology. 16 (11): 849–53. doi:10.1177/08830738010160111201. PMID 11732772. S2CID 20069074.
• Westerman BA, Poutsma A, Maruyama K, Schrijnemakers HF, van Wijk IJ, Oudejans CB (Apr 2002). "The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion". Mechanisms of Development. 113 (1): 85–90. doi:10.1016/S0925-4773(01)00665-7. PMID 11900979. S2CID 11607202.
• Westerman BA, Chhatta A, Poutsma A, van Vegchel T, Oudejans CB (Jan 2004). "NEUROD1 acts in vitro as an upstream regulator of NEUROD2 in trophoblast cells". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1676 (1): 96–103. doi:10.1016/j.bbaexp.2003.10.002. PMID 14732494.
• Zill P, Büttner A, Eisenmenger W, Bondy B (Jun 2006). "A possible impact of the neuroD2 transcription factor on the development of drug abusing behavior". Molecular Psychiatry. 11 (6): 525–7. doi:10.1038/sj.mp.4001825. PMID 16607387. S2CID 7713810.

External links

• NEUROD2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.