NCR1

Natural cytotoxicity triggering receptor 1 is a protein that in humans is encoded by the NCR1 gene. NCR1 has also been designated as CD335 (cluster of differentiation, NKP46, NKp46, NK-p46, and LY94.

NCR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OLL, 1P6F
Identifiers
Aliases	NCR1, CD335, LY94, NK-p46, NKP46, natural cytotoxicity triggering receptor 1
External IDs	OMIM: 604530; MGI: 1336212; HomoloGene: 3551; GeneCards: NCR1; OMA:NCR1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.42 Start 54,906,148 bp End 54,916,140 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 A1 Start 4,340,723 bp End 4,348,163 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood spleen bone marrow cells gonad monocyte placenta liver right lobe of liver lymph node Top expressed in blood morula spleen granulocyte gastrula right lung lobe submandibular gland extensor digitorum longus muscle uterus upper arm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane SWI/SNF complex membrane Biological process cellular defense response natural killer cell activation signal transduction regulation of immune response regulation of natural killer cell mediated cytotoxicity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9437 17086 Ensembl ENSG00000273535 ENSG00000277629 ENSG00000273916 ENSG00000275156 ENSG00000277824 ENSG00000277334 ENSG00000278362 ENSG00000275637 ENSG00000274053 ENSG00000275521 ENSG00000275822 ENSG00000277442 ENSG00000189430 ENSG00000284113 ENSG00000273506 ENSG00000276450 ENSG00000278025 ENSG00000288651 ENSMUSG00000062524 UniProt O76036 Q8C567 RefSeq (mRNA) NM_001145457 NM_001145458 NM_001242356 NM_001242357 NM_004829 NM_010746 NM_001368364 RefSeq (protein) NP_001138929 NP_001138930 NP_001229285 NP_001229286 NP_004820 NP_034876 NP_001355293 Location (UCSC) Chr 19: 54.91 – 54.92 Mb Chr 7: 4.34 – 4.35 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Biassoni R, Cantoni C, Marras D, et al. (2004). "Human natural killer cell receptors: insights into their molecular function and structure". J. Cell. Mol. Med. 7 (4): 376–87. doi:10.1111/j.1582-4934.2003.tb00240.x. PMC 6740120. PMID 14754506.
• Sivori S, Vitale M, Morelli L, et al. (1997). "p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation". J. Exp. Med. 186 (7): 1129–36. doi:10.1084/jem.186.7.1129. PMC 2211712. PMID 9314561.
• Vitale M, Bottino C, Sivori S, et al. (1998). "NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis". J. Exp. Med. 187 (12): 2065–72. doi:10.1084/jem.187.12.2065. PMC 2212362. PMID 9625766.
• Cantoni C, Bottino C, Vitale M, et al. (1999). "NKp44, A Triggering Receptor Involved in Tumor Cell Lysis by Activated Human Natural Killer Cells, Is a Novel Member of the Immunoglobulin Superfamily". J. Exp. Med. 189 (5): 787–96. doi:10.1084/jem.189.5.787. PMC 2192947. PMID 10049942.
• Vankayalapati R, Wizel B, Weis SE, et al. (2002). "The NKp46 receptor contributes to NK cell lysis of mononuclear phagocytes infected with an intracellular bacterium". J. Immunol. 168 (7): 3451–7. doi:10.4049/jimmunol.168.7.3451. PMID 11907104.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Augugliaro R, Parolini S, Castriconi R, et al. (2003). "Selective cross-talk among natural cytotoxicity receptors in human natural killer cells". Eur. J. Immunol. 33 (5): 1235–41. doi:10.1002/eji.200323896. PMID 12731048. S2CID 10724743.
• Ponassi M, Cantoni C, Biassoni R, et al. (2003). "Structure of the human NK cell triggering receptor NKp46 ectodomain". Biochem. Biophys. Res. Commun. 309 (2): 317–23. doi:10.1016/j.bbrc.2003.08.007. PMID 12951052.
• Foster CE, Colonna M, Sun PD (2003). "Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors". J. Biol. Chem. 278 (46): 46081–6. doi:10.1074/jbc.M308491200. PMID 12960161.
• Arnon TI, Achdout H, Lieberman N, et al. (2004). "The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46". Blood. 103 (2): 664–72. doi:10.1182/blood-2003-05-1716. PMID 14504081.
• Marcenaro E, Augugliaro R, Falco M, et al. (2004). "CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity". Eur. J. Immunol. 33 (12): 3367–76. doi:10.1002/eji.200324425. PMID 14635045. S2CID 40345630.
• Carbone E, Neri P, Mesuraca M, et al. (2005). "HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells". Blood. 105 (1): 251–8. doi:10.1182/blood-2004-04-1422. PMID 15328155.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mavoungou E, Bouyou-Akotet MK, Kremsner PG (2005). "Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30)". Clin. Exp. Immunol. 139 (2): 287–96. doi:10.1111/j.1365-2249.2004.02686.x. PMC 1809301. PMID 15654827.
• Nowbakht P, Ionescu MC, Rohner A, et al. (2005). "Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias". Blood. 105 (9): 3615–22. doi:10.1182/blood-2004-07-2585. PMID 15657183.
• Poggi A, Massaro AM, Negrini S, et al. (2005). "Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors". J. Immunol. 174 (5): 2653–60. doi:10.4049/jimmunol.174.5.2653. PMID 15728472.
• Zilka A, Landau G, Hershkovitz O, et al. (2006). "Characterization of the heparin/heparan sulfate binding site of the natural cytotoxicity receptor NKp46". Biochemistry. 44 (44): 14477–85. doi:10.1021/bi051241s. PMID 16262248.
• Hermann E, Alonso-Vega C, Berthe A, et al. (2006). "Human congenital infection with Trypanosoma cruzi induces phenotypic and functional modifications of cord blood NK cells". Pediatr. Res. 60 (1): 38–43. doi:10.1203/01.pdr.0000220335.05588.ea. PMID 16690951.

External links

• NCR1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: O76036 (Natural cytotoxicity triggering receptor 1) at the PDBe-KB.