Mohammed Yaqoub may refer to:
- Mohammed Yacoub (ISN 01004) is a captive held in extrajudicial detention, first in Bagram, then Guantanamo -- see Afghan captives in Guantanamo
- Mohammed Yaqoub Akhounzada, captive held in extrajudicial detention in Bagram Theater Internment Facility
- Muhammad Hussein Yacoub (born 1956), Egyptian cleric
- Mohammed Yaqoub Abbas, a sport hero, see Ajman Club
- Mohammed Yacoub Al Madadi, a former Quatari diplomat, fired after triggering a security alert aboard United Airlines Flight 663
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