Misak may refer to:
- Misak people or Guambiano, an indigenous people of Colombia
- Misak language or Guambiano, a language of Colombia
- Misak, an Armenian given name; notable people with the name include:
- Misak Metsarents (1886–1908), Armenian neo-romantic poet
- Missak Manouchian (1906–1944), French-Armenian poet and communist activist
- Misak Terzibasiyan (born 1964), Dutch architect
- Anahit Misak "Ana" Kasparian (born 1986), Armenian-American media host and journalist
- Mišak, a surname (including a list of people with the name)