M22, M.22 or M-22 may refer to:

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  • M 22, a political movement of the 1970s and 1980s in Congo-Brazzaville
  • M22, a vitrification agent or cryoprotectant, used in cryonics and cryopreservation
  • The Mathieu group M22 in the mathematical field of group theory
  • M22 graph, in graph theory
  • Messier 22, a globular cluster in the constellation Sagittarius
  • Mälar 22, sailboat class
  • M-22, a British-German DJ and producer duo consisting of Matt James and Frank Sanders.