José Núñez may refer to:
- José Núñez (politician), president of Nicaragua
- José Núñez (footballer), Spanish professional footballer
- José Núñez (right-handed pitcher) (born 1964), baseball pitcher for the Toronto Blue Jays and Chicago Cubs
- José Núñez (left-handed pitcher) (born 1979), baseball pitcher for the Los Angeles Dodgers and San Diego Padres
- Jose Nuñez (DJ), late dance music remixer and producer during the 1980s
- José Ariel Núñez, Paraguayan footballer
- Joe Núñez (José Cleto Nuñez), American politician from Colorado
This disambiguation page lists articles about people with the same name.
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