John Pyle may refer to:
- John A. Pyle (born 1951), British atmospheric scientist
- John Howard Pyle (1906–1987), ninth governor of the U.S. state of Arizona
- John L. Pyle (1860–1902), attorney and politician from the state of South Dakota
- John M. Pyle (born 1956), American fugitive from justice for possession of child pornography