John McCloskey (1810–1885) was an American Roman Catholic clergyman and first American Cardinal.
John McCloskey may also refer to:
- Henry John McCloskey (1925–2000), Australian moral philosopher
- John McCloskey (baseball manager) (1862–1940), American baseball manager
- John McCloskey (pitcher) (1882–1919), American baseball pitcher
- C. John McCloskey, Catholic priest
This disambiguation page lists articles about people with the same name.
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