Jeff Hughes may refer to:
- Jeff Hughes (fighter) (born 1988), American mixed martial artist
- Jeff Hughes (footballer) (born 1985), Northern Irish footballer
- Jeff Hughes (historian) (1965–2018), British historian of science
- Jeff Hughes (musician), American traditional jazz cornet player
- Jeff Hughes (soccer) (born 1984), American soccer player
This disambiguation page lists articles about people with the same name.
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