James Sims may refer to:
- James Sims (American football) (born 1983), American football running back
- James Sims (physician) (1741–1820), Anglo-Irish physician
- James Leland Sims (1905–1977), member of the Legislative Assembly of Alberta
- J. Marion Sims (1813–1883), American physician
This disambiguation page lists articles about people with the same name.
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