Jacob Smith may refer to:
- Jacob Smith (fur trader) (1773–1825), fur trader, American spy, and founder of Flint, Michigan
- Jacob Smith (actor) (born 1990), Laurier University
- Jacob Smith (politician) (1816–1891), ship's captain, Mayor and MHA in South Australia
- Jacob H. Smith (1840–1918), U.S. Army general during the Philippine–American War in 1901, and a veteran of the Wounded Knee Massacre
- Jacob W. Smith (1851–1926), businessman and political figure in Saskatchewan, Canada
- Jacob Getlar Smith (1898–1958), painter and muralist
- Jacob Smith (boxer), English boxer, participated in Boxing at the 1930 British Empire Games
- Jacob Smith (field hockey), played for New Zealand men's national field hockey team