HPSS may refer to:
- High Performance Storage System
- High performing specialist school, type of specialist school in the United Kingdom
- ATI HPSS (Acoustic Technology Inc. High-Power Speaker Station "Soundblaster"), an outdoor speaker system used as a warning siren
- Hilal Public School System, Green Crescent Trust, Sindh, Pakistan
- Health and Population Sector Strategy for health in Bangladesh by its government
- Croatian Peoples' Peasant Party (Croatian: HPSS), predecessor of the Croatian Peasant Party