Glutathione S-transferase Mu 1

Glutathione S-transferase Mu 1 (gene name GSTM1) is a human glutathione S-transferase.

GSTM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GTU, 1XW6, 1XWK, 1YJ6, 2F3M
Identifiers
Aliases	GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1, glutathione S-transferase mu 1
External IDs	OMIM: 138350; MGI: 95861; HomoloGene: 121492; GeneCards: GSTM1; OMA:GSTM1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p13.3 Start 109,687,814 bp End 109,709,039 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F2.3 Start 107,889,018 bp End 107,893,769 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in smooth muscle tissue gastric mucosa mucosa of transverse colon apex of heart left uterine tube testicle duodenum anterior pituitary right lobe of liver right ovary Top expressed in uterus ovary adrenal gland white adipose tissue esophagus urinary bladder lung muscle of thigh stomach testicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme binding glutathione binding protein homodimerization activity transferase activity glutathione transferase activity Cellular component cytoplasm cytosol intercellular bridge Biological process xenobiotic catabolic process nitrobenzene metabolic process cellular detoxification of nitrogen compound glutathione metabolic process metabolism glutathione derivative biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2944 14863 Ensembl ENSG00000134184 ENSMUSG00000040562 UniProt P09488 P15626 RefSeq (mRNA) NM_000561 NM_146421 NM_008183 RefSeq (protein) NP_000552 NP_666533 NP_032209 Location (UCSC) Chr 1: 109.69 – 109.71 Mb Chr 3: 107.89 – 107.89 Mb PubMed search
Wikidata
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Function

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a cytoplasmic glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress, by conjugation with glutathione.

The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3, and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins, as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.

See also

• Biliary atresia

Further reading

• Engel LS, Taioli E, Pfeiffer R, Garcia-Closas M, Marcus PM, Lan Q, et al. (July 2002). "Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review". American Journal of Epidemiology. 156 (2): 95–109. doi:10.1093/aje/kwf018. PMID 12117698.
• Navarro SL, Chang JL, Peterson S, Chen C, King IB, Schwarz Y, Li SS, Li L, Potter JD, Lampe JW (November 2009). "Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes". Cancer Epidemiology, Biomarkers & Prevention. 18 (11): 2974–8. doi:10.1158/1055-9965.EPI-09-0701. PMC 2777676. PMID 19900941.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Glutathione S-transferase Mu 1