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An antiglucocorticoid is a drug which reduces glucocorticoid activity in the body.[1] They include direct glucocorticoid receptor antagonists such as mifepristone and synthesis inhibitors such as metyrapone, ketoconazole, and aminoglutethimide. They are used to treat Cushing's syndrome.
Antiglucocorticoid | |
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Drug class | |
Class identifiers | |
Synonyms | Glucocorticoid antagonist; Cortisol antagonist; Anticorticosteroid |
Use | Cushing's syndrome, others |
Biological target | Glucocorticoid receptor |
Chemical class | Steroids |
Legal status | |
In Wikidata |
Antiglucocorticoids could be effective antidepressants for a subset of specific mood disorders, but their use is limited by side effects.
See also
editReferences
edit- ^ Muller, Caroline; Hennebert, Olivier; Morfin, Robert (2006-07-01). "The native anti-glucocorticoid paradigm". The Journal of Steroid Biochemistry and Molecular Biology. 100 (1): 95–105. doi:10.1016/j.jsbmb.2006.03.001. ISSN 0960-0760.