George Johnston may refer to:
- George Johnston (burgess) (1720–1766), American lawyer and politician
- George Johnston (British Marines officer) (1764–1823), Lieutenant-Governor of New South Wales
- George Johnston (naturalist) (1797–1855), Scottish naturalist and physician
- George Johnston (engineer) (1855–1945), Scottish engineer and motorcar designer
- George Johnston (general) (1868–1949), Australian army general and politician
- George Johnston (politician) (1884–1977), Canadian politician
- George Johnston (novelist) (1912–1970), Australian journalist and novelist
- George Johnston (ice hockey) (1920–2006), National Hockey League player
- George Johnston (footballer, born 1947), Scottish footballer
- George Johnston (footballer, born 1998), footballer for Bolton Wanderers
- George Bain Johnston (1829–1882), pioneer of River Murray, South Australia
- George Benson Johnston (1913–2004), Canadian poet
- George Doherty Johnston (1832–1910), American General and politician
- George "Blue" Johnston (1907–?), Australian rules footballer for Glenelg
- George Johnston (Australian footballer) (1877–1945), Australian rules footballer for Carlton
- George Graham Johnston (1882–1960), politician in Ontario, Canada
- George Napier Johnston (1867–1947), British Army officer who served with the New Zealand Military Forces
- George Robert Johnston (1954–2004), known as the Ballarat Bandit, burglar
- George Lawson Johnston, 1st Baron Luke (1873–1943), British businessman
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