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Summary
| Description |
English: Flaviviral replication complex assembled on the cytoplasmic side of the ER membrane. The viral replication complex is associated with the virus vesicle (single membrane vesicle) formed by invagination of the ER membrane. Interactions between flaviviral NS proteins are indicated schematically. Viral membrane proteins NS2A, NS2B, NS4A, and NS4B form a scaffold for the assembly of NS3 and NS5 proteins. Oligomerization of NS4A and dimerization of NS4B are depicted [51,52]. NS3 interacts with NS2B through its protease domain and with NS4B through its helicase domain. NS5 interacts only with NS3. The NS1 dimer is located in the ER lumen, and associates with NS4A and NS4B. |
| Date | |
| Source |
Klema, V.J.; Padmanabhan, R.; Choi, K.H. Flaviviral Replication Complex: Coordination between RNA Synthesis and 5’-RNA Capping. Viruses 2015, 7, 4640-4656. https://www.mdpi.com/1999-4915/7/8/2837/htm |
| Author | Valerie J. Klema, Radhakrishnan Padmanabhan, and Kyung H. Choi |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 10:21, 26 November 2020 | | 3,161 × 1,717 (658 KB) | Guest2625 | Uploaded a work by Valerie J. Klema, Radhakrishnan Padmanabhan, and Kyung H. Choi from Klema, V.J.; Padmanabhan, R.; Choi, K.H. Flaviviral Replication Complex: Coordination between RNA Synthesis and 5’-RNA Capping. Viruses 2015, 7, 4640-4656. https://www.mdpi.com/1999-4915/7/8/2837/htm with UploadWizard |
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