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Summary
| Description |
English: Mechanistic overview between chaperone-mediated autophagy and macroautophagy. In chaperone-mediate autophagy, the Hsc70 complex binds proteins with a KFERQ sequence, translocating the protein to the lysosome where it enters via LAMP2a. In macroautophagy, select proteins or whole organelles are engulfed by an autophagosome, which fuses with the lysosomal membrane and releases its contents. In both pathways, substrates that enter the lysosome are degraded by acid hydrolases. |
| Date | |
| Source | Ghosh, R., & Pattison, J. S. (2018). Macroautophagy and chaperone-mediated autophagy in heart failure: The known and the unknown. Oxidative Medicine and Cellular Longevity, 2018. |
| Author | Rajeshwary Ghosh and J. Scott Pattison |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 13:07, 10 December 2020 | | 1,705 × 1,379 (1,018 KB) | Jlibera1 | Uploaded a work by Rajeshwary Ghosh and J. Scott Pattison from Ghosh, R., & Pattison, J. S. (2018). Macroautophagy and chaperone-mediated autophagy in heart failure: The known and the unknown. Oxidative Medicine and Cellular Longevity, 2018. with UploadWizard |
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