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| Description | http://www.biomedcentral.com/1471-2105/8/365
Design of a computational gene. A) Most eukaryotic genes are organized as alternating sequences of coding (exons) and non-coding (introns) segments. Conserved regions in the introns, e.g., pyrimidine rich region (poly(Y)), 5'-splice junction (AG/GTGAG), AG dinucleotide at the 3'-splice junction, and branch point sequence (CTCAT) guarantee proper splicing. These conserved regions are maintained in the structural moiety of the computational gene. B) Schematic representation of self-assembled (functional) gene encoding a diagnostic rule for 2 mutations (n=2). The initial state comprises promoter, first exon, and 5'-splicing site, the transition rules are placed in the intron region, and the final state includes branch site, poly(Y)-region, 3'-splice site, and second exon. C) Finite state automaton implementing a diagnostic rule for n mutations. |
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| Source |
Martinez-Perez, I.M., Zhang, G., Ignatova, Z., Zimmermann, K.-H.: Computational genes: a tool for the molecular diagnosis and therapy of aberrant mutational phenotype. BMC Bioinformatics 2007, 8:365. |
| Date |
28 September 2007 |
| Author |
Martinez-Perez et al. |
| Permission (Reusing this file) |
GFDL
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| current | 19:15, 25 January 2008 | | 842 × 595 (50 KB) | Biomol (talk | contribs) | {{Information |Description= Design of a computational gene. A) Most eukaryotic genes are organized as alternating sequences of coding (exons) and non-coding (introns) segments. Conserved regions in the introns, e.g., pyrimidine rich region (poly(Y)), 5'- |
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