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Summary
| Description |
English: Summary of topoisomerase types and catalytic mechanisms. The topoisomerases are categorised based on whether they catalyse single- (type I) or double-stranded (type II) DNA breaks. The type I topoisomerases are further subdivided to type IA, IB and IC. Type IA form a transient covalent bond to the 5ʹ DNA phosphate and function via a strand passage mechanism. Type IB and IC form a transient covalent bond to the 3ʹ DNA phosphate and function via a controlled-rotation mechanism. Type II topoisomerases are further subdivided into type IIA and IIB. Both form a transient covalent bond to the 5ʹ DNA phosphate of both strands of the duplex and function via a strand-passage mechanism |
| Date | |
| Source | Own work |
| Author | Kcneuman |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 06:11, 10 April 2022 | | 1,841 × 444 (72 KB) | Kcneuman | Uploaded own work with UploadWizard |
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