Excitatory amino acid transporter 4

Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene.[5][6]

SLC1A6
Identifiers
AliasesSLC1A6, EAAT4, solute carrier family 1 member 6
External IDsOMIM: 600637; MGI: 1096331; HomoloGene: 21055; GeneCards: SLC1A6; OMA:SLC1A6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_009200

RefSeq (protein)

NP_001259016
NP_001259017
NP_005062

NP_033226

Location (UCSC)Chr 19: 14.95 – 15.02 MbChr 10: 78.62 – 78.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions.[6]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105143Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005357Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: solute carrier family 1 (high affinity aspartate/glutamate transporter)".
  6. ^ a b Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG (June 1995). "An excitatory amino-acid transporter with properties of a ligand-gated chloride channel". Nature. 375 (6532): 599–603. Bibcode:1995Natur.375..599F. doi:10.1038/375599a0. PMID 7791878. S2CID 4334983.

Further reading

edit