Enoyl-CoA hydratase 2 (2-enoyl-CoA hydratase 2, AtECH2, ECH2, MaoC, MFE-2, PhaJAc, D-3-hydroxyacyl-CoA hydro-lyase, D-specific 2-trans-enoyl-CoA hydratase) is an enzyme (EC 4.2.1.119) with systematic name (3R)-3-hydroxyacyl-CoA hydro-lyase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction on D-3-hydroxyacyl-CoA
| Enoyl-CoA hydratase 2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.1.119 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme catalyses a hydration step in peroxisomal beta oxidation.
References
edit- ^ Koski KM, Haapalainen AM, Hiltunen JK, Glumoff T (February 2005). "Crystal structure of 2-enoyl-CoA hydratase 2 from human peroxisomal multifunctional enzyme type 2". Journal of Molecular Biology. 345 (5): 1157–69. doi:10.1016/j.jmb.2004.11.009. PMID 15644212.
- ^ Fukui T, Shiomi N, Doi Y (February 1998). "Expression and characterization of (R)-specific enoyl coenzyme A hydratase involved in polyhydroxyalkanoate biosynthesis by Aeromonas caviae". Journal of Bacteriology. 180 (3): 667–73. PMC 106937. PMID 9457873.
- ^ Koski MK, Haapalainen AM, Hiltunen JK, Glumoff T (July 2003). "Crystallization and preliminary crystallographic data of 2-enoyl-CoA hydratase 2 domain of Candida tropicalis peroxisomal multifunctional enzyme type 2". Acta Crystallographica Section D. 59 (Pt 7): 1302–5. doi:10.1107/s090744490300982x. PMID 12832794.
- ^ Hisano T, Fukui T, Iwata T, Doi Y (January 2001). "Crystallization and preliminary X-ray analysis of (R)-specific enoyl-CoA hydratase from Aeromonas caviae involved in polyhydroxyalkanoate biosynthesis" (PDF). Acta Crystallographica Section D. 57 (Pt 1): 145–7. doi:10.1107/s0907444900014062. PMID 11134939.
- ^ Goepfert S, Hiltunen JK, Poirier Y (November 2006). "Identification and functional characterization of a monofunctional peroxisomal enoyl-CoA hydratase 2 that participates in the degradation of even cis-unsaturated fatty acids in Arabidopsis thaliana". The Journal of Biological Chemistry. 281 (47): 35894–903. doi:10.1074/jbc.m606383200. PMID 16982622.
- ^ Engeland K, Kindl H (August 1991). "Evidence for a peroxisomal fatty acid beta-oxidation involving D-3-hydroxyacyl-CoAs. Characterization of two forms of hydro-lyase that convert D-(-)-3-hydroxyacyl-CoA into 2-trans-enoyl-CoA". European Journal of Biochemistry. 200 (1): 171–8. doi:10.1111/j.1432-1033.1991.tb21064.x. PMID 1879422.
External links
edit- Enoyl-CoA+hydratase+2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
