Edward, Duke of Guimarães may refer to:
- Duarte, Duke of Guimarães (1515–1540), son of King Manuel I of Portugal and Maria of Aragon, married Isabel of Braganza.
- Duarte, Duke of Guimarães (1541–1576), son of the previous and his wife, Isabel of Braganza, never married.
This disambiguation page lists articles associated with the title Edward, Duke of Guimarães.
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