This article contains paid contributions. It may require cleanup to comply with Wikipedia's content policies, particularly neutral point of view. |
The Kahn-Sagol-Maccabi (KSM) for Research and Innovation (in Hebrew: מכון קאהן-סגול-מכבי למחקר ולחדשנות) is the Research and Innovation Center of Maccabi Healthcare Services.[1]
מכון קאהן-סגול-מכבי למחקר ולחדשנות (Hebrew) | |
![]() | |
Type | Medical research |
---|---|
Established | 2016 |
Location | Israel |
Website | www |
History
editFounded in 2016 by Maccabi Health Services with the key support of Morris Kahn and Sami Sagaol, KSM promotes excellence in medical research.[2]
Formerly headed by Prof. Varda Shalev and currently headed by Dr. Tal Patalon, an active clinician specializing in family and emergency medicine and a dedicated researcher,[3] KSM comprises four specialized research departments: Big Data,[4] Biobank (housing Israel's largest biological sample database for research),[5] Clinical Studies,[6] and Epidemiological Studies.[7]
In its global outreach, KSM collaborates with leading technology firms, start-up companies,[8] academic institutions[9] and scientists worldwide,[10] and has forged research agreements with numerous health ministries,[11][12] including those of United Arab Emirates[13] and Bahrain.[14]
Activities and services
editMedical studies
editKSM Center strives to enhance healthcare systems through independent research and partnerships with international researchers,[15] academic institutions, pharmaceutical companies, start-ups and technology firms.[16][17]
Since its inception, the center has conducted hundreds of studies,[18] resulting in the development of tools for both patients and healthcare providers.[19] These studies have influenced medical policies in several countries, particularly during the COVID-19 pandemic.[20]
Notable studies conducted under KSM's auspices include:
- Studies on the coronavirus epidemic – During the COVID-19 pandemic, several international scientific studies based on the Maccabi databases were conducted by the center, Including studies on repeated infection in children,[21] repeated infection in adults,[22] natural vaccination,[23][20][24] reduction of transmission[25] the decline in the effect of the third vaccine[26] the effect of the vaccine on intra-domestic infection[9] and on patients with Coeliac disease.[27]
- Research on monkeypox – In 2023, a study on monkeypox based on KSM's analysis and database was published.[28]
- Research on Parvovirus B19 – In 2023, a study on a local outbreak of parvovirus was published.[29]
- Research on autism – In 2023, a study on late diagnosis of autism was published.[30]
- Research on cancer – In 2023, a study of the effects of palbociclib treatment on the lifespan of patients with breast cancer was published.[31]
Medical database
editKSM's research activities are based on independent efforts, as well as the extensive medical knowledge and database of Maccabi Health Services.[32] This database, compiled over three decades and anonymized, encompasses digital records of 2.7 million insured individuals.[33]
In addition to its in-house research,[34] the Center offers global researchers access to conduct studies, analyses [30] and medical prediction,[35] based on this comprehensive database.[36]
KSM's innovation and big data department leverages databases and artificial intelligence technologies,[37][38] facilitating a wide range of research opportunities, analysis and medical prediction.[39]
Biobank
editThe KSM Center has established the Tipa BioBank,[5] Israel's largest biobank[40] housing over a million genetic samples for research purposes.[11][19]
The purpose of this initiative is to develop tools for early disease detection through genetic[41] and biological studies.[8] A central feature of this effort is the creation of a repository of biological samples (e.g., blood, urine, etc.), enabling researchers to investigate how genetic profiles influence disease risk and treatment.[42]
Main publications
edit- Gazit, Sivan; Saciuk, Yaki; Perez, Galit; Peretz, Asaf; Ben-Tov, Amir; Stuart, Elizabeth A.; Patalon, Tal (2023). "Hybrid immunity against reinfection with SARS-CoV-2 following a previous SARS-CoV-2 infection and single dose of the BNT162b2 vaccine in children and adolescents: A target trial emulation". The Lancet Microbe. 4 (7): e495–e505. doi:10.1016/S2666-5247(23)00103-9. PMC 10101759. PMID 37062294.
- Shapira, Guy; Patalon, Tal; Gazit, Sivan; Shomron, Noam (2023). "Immunosuppression as a Hub for SARS-CoV-2 Mutational Drift". Viruses. 15 (4): 855. doi:10.3390/v15040855. PMC 10145566. PMID 37112835.
- Patalon, Tal; Saciuk, Yaki; Perez, Galit; Peretz, Asaf; Ben-Tov, Amir; Gazit, Sivan (2023). "Dynamics of Naturally Acquired Immunity Against Severe Acute Respiratory Syndrome Coronavirus 2 in Children and Adolescents". The Journal of Pediatrics. 257. doi:10.1016/j.jpeds.2023.02.016. PMC 9981270. PMID 36870558.
- Gazit, Sivan; Shlezinger, Roei; Perez, Galit; Lotan, Roni; Peretz, Asaf; Ben-Tov, Amir; Herzel, Esma; Alapi, Hillel; Cohen, Dani; Muhsen, Khitam; Chodick, Gabriel; Patalon, Tal (2022). "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Naturally Acquired Immunity versus Vaccine-induced Immunity, Reinfections versus Breakthrough Infections: A Retrospective Cohort Study". Clinical Infectious Diseases. 75 (1): e545–e551. doi:10.1093/cid/ciac262. PMC 9047157. PMID 35380632.
- Gazit, Sivan; Shlezinger, Roei; Perez, Galit; Lotan, Roni; Peretz, Asaf; Ben-Tov, Amir; Herzel, Esma; Alapi, Hillel; Cohen, Dani; Muhsen, Khitam; Chodick, Gabriel; Patalon, Tal (2022). "The Incidence of SARS-CoV-2 Reinfection in Persons with Naturally Acquired Immunity with and Without Subsequent Receipt of a Single Dose of BNT162b2 Vaccine". Annals of Internal Medicine. 175 (5): 674–681. doi:10.7326/M21-4130. PMC 8855786. PMID 35157493.
- Ben-Tov, Amir; Lebwohl, Benjamin; Banon, Tamar; Chodick, Gabriel; Kariv, Revital; Assa, Amit; Gazit, Sivan; Patalon, Tal (2023). "BNT162b2 mRNA COVID-19 Vaccine Effectiveness in Patients with Coeliac Disease Autoimmunity: Real-World Data from Mass Vaccination Campaign". Viruses. 15 (9): 1968. doi:10.3390/v15091968. PMC 10534420. PMID 37766374.
- Lechtman, Niva; Shamir, Raanan; Cohen, Shlomi; Chodick, Gabriel; Kariv, Revital; Supino-Rosin, Lia; Weintraub, Yael; Yerushalmy-Feler, Anat; Ben Tov, Amir (2021). "Increased incidence of coeliac disease autoimmunity rate in Israel: A 9-year analysis of population-based data". Alimentary Pharmacology & Therapeutics. 53 (6): 696–703. doi:10.1111/apt.16282. PMID 33547687. S2CID 231946967.
References
edit- ^ The Kahn-Sagol-Maccabi (KSM) Institute for Research and Innovation
- ^ "Kahn Sagol Maccabi". Guidestar. Retrieved 9 November 2023.
- ^ Rubinstein, Carrie (8 March 2023). "AI Is Taking Over Our Feelings: An Economist's Positive-Negative Prediction Of The Near Future". Forbes. Retrieved 26 October 2023.
- ^ Big data unit Kahn-Sagol-Maccabi (KSM)
- ^ a b The Tipa Biobank, Kahn-Sagol-Maccabi (KSM)
- ^ Clinical trial unit Kahn-Sagol-Maccabi (KSM)
- ^ Epidemiological studies, Kahn-Sagol-Maccabi (KSM)
- ^ a b Rubinstein, Carrie (12 July 2023). "Apparently Getting Smarter Makes Us Healthier: AI And Data Analysis Revolutionize Healthcare". Forbes. Retrieved 26 October 2023.
- ^ a b Prunas, Ottavia; Warren, Joshua L.; Crawford, Forrest W.; Gazit, Sivan; Patalon, Tal; Weinberger, Daniel M.; Pitzer, Virginia E. (2022). "Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel". Science. 375 (6585): 1151–1154. Bibcode:2022Sci...375.1151P. doi:10.1126/science.abl4292. PMC 9261115. PMID 35084937.
- ^ Kahn-Sagol-Maccabi (KSM), Maccabi Healthcare Services
- ^ a b "Abu Dhabi DoH and Kahn Sagol Maccabi (KSM) Sign an MoU to Cooperate in Technological Innovation and Healthcare Research". AP news. 1 February 2023. Retrieved 26 October 2023.
- ^ "Abu Dhabi health dept., Israeli health org pledge to cooperate on research". Jerusalem Post. 2 February 2023. Retrieved 26 October 2023.
- ^ "New UAE-Israel agreement to promote cancer, diabetes research". Khaleej Times. 13 July 2022. Retrieved 26 October 2023.
- ^ "Healing relationship – Bahrain and Maccabi in a strategic and groundbreaking research and innovation agreement". Ynet. 10 May 2022. Retrieved 26 October 2023.
- ^ Neesha Salian, SEHA and Israel’s leading HMO announce collaboration in research and digital health development, Gulf Business, 13 July 2022
- ^ Maccabi’s KSM Research and Innovation Center Announces Partnership with Rhino Health to Facilitate Healthcare Data Collaborations, Accesswire 25 October 2022
- ^ PrognomiQ, Maccabi Health Collaborating on Cancer Biomarker Development, 360dx.com, 21 June 2022
- ^ Professional publications, KSM Research and Innovation Center
- ^ a b Rubinstein, Carrie (9 September 2022). "Small-Big Data: A Healthcare Revolution In The Making". Forbes. Retrieved 26 October 2023.
- ^ a b Patalon, Tal; Saciuk, Yaki; Perez, Galit; Peretz, Asaf; Ben-Tov, Amir; Gazit, Sivan (2023). "Dynamics of Naturally Acquired Immunity Against Severe Acute Respiratory Syndrome Coronavirus 2 in Children and Adolescents". The Journal of Pediatrics. 257. doi:10.1016/j.jpeds.2023.02.016. PMC 9981270. PMID 36870558.
- ^ Gazit, Sivan; Saciuk, Yaki; Perez, Galit; Peretz, Asaf; Ben-Tov, Amir; Stuart, Elizabeth A.; Patalon, Tal (2023). "Hybrid immunity against reinfection with SARS-CoV-2 following a previous SARS-CoV-2 infection and single dose of the BNT162b2 vaccine in children and adolescents: A target trial emulation". The Lancet Microbe. 4 (7): e495–e505. doi:10.1016/S2666-5247(23)00103-9. PMC 10101759. PMID 37062294.
- ^ Gazit, S.; Shlezinger, R.; Perez, G.; Lotan, R.; Peretz, A.; Ben-Tov, A.; Herzel, E.; Alapi, H.; Cohen, D.; Muhsen, K.; Chodick, G.; Patalon, T. (2022). "The Incidence of SARS-CoV-2 Reinfection in Persons with Naturally Acquired Immunity with and Without Subsequent Receipt of a Single Dose of BNT162b2 Vaccine: A Retrospective Cohort Study". Annals of Internal Medicine. 175 (5): 674–681. doi:10.7326/M21-4130. PMC 8855786. PMID 35157493.
- ^ Patalon, Tal; Saciuk, Yaki; Perez, Galit; Peretz, Asaf; Ben-Tov, Amir; Gazit, Sivan (2023). "Dynamics of Naturally Acquired Immunity Against Severe Acute Respiratory Syndrome Coronavirus 2 in Children and Adolescents". The Journal of Pediatrics. 257. doi:10.1016/j.jpeds.2023.02.016. PMC 9981270. PMID 36870558.
- ^ Patalon, Tal; Saciuk, Yaki; Perez, Galit; Peretz, Asaf; Ben-Tov, Amir; Gazit, Sivan (2023). "Dynamics of Naturally Acquired Immunity Against Severe Acute Respiratory Syndrome Coronavirus 2 in Children and Adolescents". The Journal of Pediatrics. 257. doi:10.1016/j.jpeds.2023.02.016. PMC 9981270. PMID 36870558.
- ^ van Boven, Michiel; van Dorp, Christiaan H.; Westerhof, Ilse; et al. (29 January 2024). "Estimation of introduction and transmission rates of SARS-CoV-2 in a prospective household study". PLOS Computational Biology. 20 (1): e1011832. doi:10.1371/journal.pcbi.1011832. ISSN 1553-7358. medRxiv 10.1101/2023.06.02.23290879. PMC 10852262. PMID 38285727.
- ^ Patalon, Tal; Saciuk, Yaki; Peretz, Asaf; Perez, Galit; Lurie, Yoav; Maor, Yasmin; Gazit, Sivan (2022). "Waning effectiveness of the third dose of the BNT162b2 mRNA COVID-19 vaccine". Nature Communications. 13 (1): 3203. Bibcode:2022NatCo..13.3203P. doi:10.1038/s41467-022-30884-6. PMC 9184525. PMID 35680872.
- ^ Ben-Tov, Amir; Lebwohl, Benjamin; Banon, Tamar; Chodick, Gabriel; Kariv, Revital; Assa, Amit; Gazit, Sivan; Patalon, Tal (2023). "BNT162b2 mRNA COVID-19 Vaccine Effectiveness in Patients with Coeliac Disease Autoimmunity: Real-World Data from Mass Vaccination Campaign". Viruses. 15 (9): 1968. doi:10.3390/v15091968. PMC 10534420. PMID 37766374.
- ^ Patalon, Tal; Perez, Galit; Saciuk, Yaki; Refaeli, Ziva; Gazit, Sivan (2023). "Mpox Patient Journey in Israel". Microorganisms. 11 (4): 1042. doi:10.3390/microorganisms11041042. PMC 10145053. PMID 37110465.
- ^ Patalon, Tal; Saciuk, Yaki; Trotzky, Daniel; Pachys, Gal; Ben-Tov, Amir; Segal, Yaakov; Gazit, Sivan (2023). "An Outbreak of Parvovirus B19 in Israel". Viruses. 15 (11): 2261. doi:10.3390/v15112261. PMC 10674631. PMID 38005937.
- ^ Davidovitch, Michael; Gazit, Sivan; Patalon, Tal; Leitner, Yael; Rotem, Ran S. (2023). "Late diagnosis of autism spectrum disorder—Journey, parents' concerns, and sex influences". Autism Research. 16 (2): 294–301. doi:10.1002/aur.2869. PMID 36495248. S2CID 254561408.
- ^ Moser, Sarah Sharman; Mazursky, Orr Friedman; Shalev, Hadas; Apter, Lior; Chodick, Gabriel; Siegelmann-Danieli, Nava (2023). "Real-world outcomes of patients with metastatic endocrine-responsive breast cancer receiving palbociclib-based combinations". Future Oncology. 19 (21): 1473–1483. doi:10.2217/fon-2023-0176. PMID 37529919.
- ^ Valo Health, KSM research and innovation center and Valo health announce first of its kind multiyear collaboration to spearhead preventive care and personalized medicine for patients, 19 Sep 2022
- ^ Kraus, Yair (1 August 2023). ""Artificial intelligence is going to lead to a change the likes of which we haven't seen in years in the world of medicine"". Ynet. Retrieved 9 November 2023.
- ^ Yanko, Adir (25 March 2021). "A significant increase in the diagnosis of young celiac patients in Israel – what are the reasons for this?". Ynet. Retrieved 26 October 2023.
- ^ Yechezkel, Matan; Mofaz, Merav; Painsky, Amichai; Patalon, Tal; Gazit, Sivan; Shmueli, Erez; Yamin, Dan (2023). "Safety of the fourth COVID-19 BNT162b2 mRNA (Second booster) vaccine: A prospective and retrospective cohort study". The Lancet Respiratory Medicine. 11 (2): 139–150. doi:10.1016/S2213-2600(22)00407-6. PMC 9889528. PMID 36410364.
- ^ Weinerb, Gali (1 December 2020). "Predicting illnesses and hospitalizations: the vision of the director of the Maccabi Research Institute". Globes. Retrieved 26 October 2023.
- ^ Danny Sullivan, Longevity AI partners with Israel’s leading HMO, Technology, 4 April 2023
- ^ IBEX Introduces Galen Gastric, World’s First AI-Powered Solution For Gastrointestinal Cancer Diagnostics, At Maccabi Healthcare Services, AIthority.com, 24 August 2021
- ^ Suresh, Somasetty (25 October 2023). "New Study Shows Pfizer COVID-19 Vaccine Equally Effective for Patients with Celiac Disease". Express Healthcare Management. Retrieved 26 October 2023.
- ^ KSM Research And Innovation And Genetika+ Partner To Seek AI Solutions For Personalization Of Depression Treatment, 15 August 2022
- ^ G42 Healthcare, KSM enter first UAE-Israel genetic research collaboration – Arabian Business, Arabian Business, 2 March 2022
- ^ Israel and UAE to collaborate on cancer and diabetes research, MiddleEastMonitor ,14 July 2022