Jeffry B. Lansman (born 1951, in Miami Beach, Florida) is an American neuroscientist, professor emeritus of Cellular and Molecular Pharmacology in the School of Medicine of the University of California, San Francisco, and member of UCSF's Weill Institute for Neurosciences and Cardiovascular Research Institute. He is also a Senior Scientific Advisor to Cardio AI, a precision cardiovascular care company advancing AI-enhanced rapid diagnosis and treatment of cardiovascular disease.
Career
editLansman studied biology at Purchase College (Bachelor of Science), and Tufts University (Master of Science) and subsequently received a Ph.D. in Physiology and Biophysicd at UCLA School of Medicine under Susumu Hagiwara. He went on to complete postdoctoral training at the Yale School of Medicine and the Physiological Laboratory at the University of Cambridge.
He joined the faculty of the Department of Pharmacology at UCSF School of Medicine as an Assistant Professor where he received tenure as Associate Professor and then became Professor of Cellular & Molecular Pharmacology.[1]
Lansman is known for his research on calcium channels in nerve and muscle and their role in normal physiology and in disease. His early work on marine invertebrates discovered the hyperpolarization-activated ion channels that produce the rhythmic beating of the heart. While working at Yale School of Medicine with Richard W. Tsien and Peter Hess, he discovered the L-type and T-type channels in heart muscle that control heart rate and contractility. He subsequently discovered ion channels that transduce mechanical forces into the entry of calcium into blood vessels and skeletal muscle and contribute to vascular regulation and muscle degeneration in muscular dystrophy.
In 2017, he founded Turex Marine Biopharma to explore marine biomes and discover new drugs for treating neurodegenerative diseases.
Most cited papers
edit- Hess, P., Lansman, J.B. and Tsien, R.W. (1984) Different modes of calcium channel gating behavior favored by dihydropyridine agonists and antagonists. Nature 311:538-544. (Cited 1587 times[2])
- Nilius, B., Hess, P., Lansman, J.B. and Tsien, R.W. (1985) A novel type of cardiac calcium channel in ventricular cells. Nature 316:443-446. (Cited 930 times[2])
- Lansman, J.B., Hallam, T.J. and Rink, T.J. (1987) Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers? Nature 325:811-813. (Cited 905 times[2])
- Hess, P., Lansman, J.B. and Tsien, R.W. (1986) Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells. Journal of General Physiology 88:293-319. (Cited 683 times[2])
- Lansman, J.B., Hess, P. and Tsien, R.W. (1986) Blockade of current through single calcium channels by Cd, Mg, and Ca. Voltage-and concentration-dependence of Ca entry into the pore. Journal of General Physiology 88:321-347. (Cited 638 times[2])
References
edit- ^ "Jeff Lansman". UCSF Profiles. Retrieved 2023-12-27.
- ^ a b c d e "Jeff Lansman". Google Scholar. Retrieved 26 December 2023.