Wikipedia

Draft:Chinfei Chen


Introduction edit

Chinfei Chen is an American neuroscientist and member of the American Academy of Arts and Sciences studying synaptic plasticity.[1][2][3][4][5][6] She currently serves as a Professor of Neurology and neurobiology at Harvard Medical School[7] and the Associate Director of the Harvard Program in Neuroscience[8].She also works as a Research Associate in Neurology at the Boston Children's Hospital[9].

Early Life edit

Chinfei Chen, born in the United States to Taiwanese immigrants, spent her early years in Wilmington, Delaware.[10] Her father had previously moved to the United States to pursue a graduate degree in architecture.[10] As Chen grew older, she and her family relocated to New York City, where she received her education through the city's public school system.[10]

Education and Training edit

While in New York, Chen went to Stuyvesant High School.[10] She attended the University of Pennsylvania to pursue a Bachelor of Applied Science in engineering.[10] During her undergraduate years, she joined Britton Chance's laboratory, where she studied brain activity by monitoring flavoprotein fluorescence.[10] Chen later obtained her M.D. and Ph.D. from Harvard Medical School.[10] While in graduate school, she first worked with Edward Kravitz to research neurotransmitter signaling pathways in lobsters.[10] She then worked with Peter Hess on calcium channel biophysics for her Ph.D. Chen then completed her residency in adult neurology at Massachusetts General Hospital.[10][11], followed by postdoctoral training with Wade Regehr at Harvard Medical School.[10][11] Chen decided to study the thalamus during her postdoctoral training, after seeing a patient with damage to the mediodorsal thalamus during her residency.[10]

Research edit

Chen's research focuses on mechanisms of synaptic and circuit plasticity in the mammalian central nervous system, for which she was recognized by the American Academy of Arts and Sciences.[12][1] Chen's research uncovered the functional organization of retinal inputs into the visual thalamus[12] and insight into synaptic function of visual pathways in mouse model of autism and Rett Syndrome [13].

Personal Life edit

In her free time outside of the lab, Chen gardens and creates floral arrangements and is a fan of Boston Red Sox.[10] After being gifted hockey gear from her husband, Chen learned how to play ice hockey and enjoys the sport for exercise.[10]

Selected Publications[5] edit

  • Hooks BM, Chen C. Distinct roles for spontaneous and visual activity in remodeling of the retinogeniculate synapse.  Neuron 2006; 52:281-291. PMID: 17046691 DOI: 10.1016/j.neuron.2006.07.007
  • Hooks BM, Chen C.  Vision triggers an experience-dependent sensitive period at the retinogeniculate synapse.  J Neurosci 2008 28:4807-4817. PMID: 18448657 DOI: 10.1523/JNEUROSCI.4667-07.2008
  • Noutel J, Hong YK, Leu BH, Kang E and Chen C.  Experience-Dependent Retinogeniculate Synapse Remodeling is Abnormal in MeCP2 deficient mice. Neuron 2011; 70:35-42. PMCID: PMC3082316 DOI: 10.1016/j.neuron.2011.03.001
  • Hong YK, Park K, Litvina E, Morales J, Sanes JR and Chen C. Bouton Clustering Underlies Retinogeniculate Refinement. Neuron 2014; 84: 332-339.  PMID: 25284005 DOI: 10.1016/j.neuron.2014.08.059
  • Thompson AD, Picard N, Min L, Fagiolini M and Chen C. Cortical Feedback Regulates Feedforward Retinogeniculate Refinement.  Neuron, 2016; 91:1021-1033. PMID: 27545712 DOI: 10.1016/j.neuron.2016.07.040
  • Litvina EY and Chen C.  Functional Convergence at the Retinogeniculate Synapse. Neuron 2017; 96:330-338. PMID: 29024658 DOI: 10.1016/j.neuron.2017.09.037
  • Liang L, Fratzl A, Goldey G, Ramesh RN, Sugden AU, Morgan JL, Chen C* and Andermann ML*. A fine-scale functional logic to convergence from retina to thalamus. Cell 2018; 173:1343-1355 PMID: 29856953 DOI: 10.1016/j.cell.2018.04.041
  • Reggiani JDS, Jiang Q, Barbini M, Lutas A, Liang L, Fernando J, Deng F, Wan J, Li Y, Chen C*, Andermann ML*.  Brainstem Serotonin Neurons Selectively Gate Retinal Information Flow to Thalamus. 2022. Neuron Dec 21:S0896-6273(22)01079-0. PMID: 36584680 DOI: 10.1016/j.neuron.2022.12.006

References edit

  1. ^ a b "2024 New Member List | American Academy of Arts and Sciences". www.amacad.org. Retrieved 2024-04-29.
  2. ^ "Newsroom | Two Boston Children's Hospital Researchers Elected to The American Academy of Arts & Sciences | Boston Children's Hospital". www.childrenshospital.org. Retrieved 2024-04-29.
  3. ^ "2024 New Member List | American Academy of Arts and Sciences". www.amacad.org. Retrieved 2024-04-29.
  4. ^ "News & Research". hms.harvard.edu. Retrieved 2024-04-29.
  5. ^ a b "Chen, Chinfei[Full Author Name] - Search Results - PubMed". PubMed. Retrieved 2024-04-26.
  6. ^ "Balancing the Brain | Nursing Today. Nursing Journals : American Society of Registered Nurses". www.asrn.org. Retrieved 2024-04-29.
  7. ^ "Rett protein alters visual circuits in mice". Spectrum | Autism Research News. 2011-05-23. Retrieved 2024-04-29.
  8. ^ "Harvard PhD Program in Neuroscience". pinphd.hms.harvard.edu. Retrieved 2024-05-08.
  9. ^ "Chinfei Chen". Harvard Brain Science Initiative. Retrieved 2024-04-26.
  10. ^ a b c d e f g h i j k l m "Episode 24: Chinfei Chen, MD PhD". Conjugate: Illustration and Science Blog. Retrieved 2024-04-26.
  11. ^ a b "Chinfei Chen". ERM 2019. Retrieved 2024-04-29.
  12. ^ a b "Scientists Visualize the Connections Between Eye and Brain". www.bidmc.org. Retrieved 2024-04-29.
  13. ^ Roan, Shari; Times, Los Angeles (2011-04-15). "Rodent of the Week: Possible reason autism symptoms sometimes appear later". Los Angeles Times. Retrieved 2024-05-08.
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