DGKB

Diacylglycerol kinase beta is an enzyme that in humans is encoded by the DGKB gene.

DGKB
Identifiers
Aliases	DGKB, DAGK2, DGK, DGK-BETA, diacylglycerol kinase beta
External IDs	OMIM: 604070; MGI: 2442474; HomoloGene: 37875; GeneCards: DGKB; OMA:DGKB - orthologs
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 A3 Start 37,867,725 bp End 38,684,238 bp
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in dorsal striatum olfactory tubercle mammillary body dentate gyrus of hippocampal formation granule cell superior frontal gyrus piriform cortex globus pallidus nucleus accumbens lateral septal nucleus temporal lobe BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding calcium ion binding ATP binding metal ion binding kinase activity diacylglycerol kinase activity NAD+ kinase activity Cellular component cytoplasm nucleus cytosol plasma membrane Schaffer collateral - CA1 synapse glutamatergic synapse Biological process platelet activation protein kinase C-activating G protein-coupled receptor signaling pathway intracellular signal transduction phosphorylation glycerolipid metabolic process lipid phosphorylation metabolism signal transduction response to bacterium modulation of chemical synaptic transmission regulation of postsynapse organization diacylglycerol metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1607 217480 Ensembl ENSG00000136267 ENSMUSG00000036095 UniProt Q9Y6T7 Q6NS52 RefSeq (mRNA) NM_004080 NM_145695 NM_178681 NM_001361686 NM_001361688 RefSeq (protein) NP_663733 NP_001337634 NP_001337635 NP_001337636 NP_001337637 NP_001337638 NP_001337640 NP_001337641 NP_001337643 NP_001337644 NP_001337645 NP_001337646 NP_001337647 NP_001337648 NP_001337649 NP_001337650 NP_001337651 NP_001337652 NP_001337653 NP_848796 NP_001348615 NP_001348617 Location (UCSC) n/a Chr 12: 37.87 – 38.68 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene.

Further reading

• Caricasole A, Bettini E, Sala C, Roncarati R, Kobayashi N, Caldara F, Goto K, Terstappen GC (February 2002). "Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties". The Journal of Biological Chemistry. 277 (7): 4790–6. doi:10.1074/jbc.M110249200. PMID 11719522.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.