De Güemes is a surname, and may refer to:
- Juan Francisco de Güemes y Horcasitas, 1st Count of Revillagigedo (1681–1766), Spanish general, governor of Havana, captain general of Cuba, and viceroy of New Spain
- Juan Vicente de Güemes Padilla Horcasitas y Aguayo, 2nd Count of Revillagigedo (1740–1799), Spanish military officer and viceroy of New Spain
- Martín Miguel de Güemes (1785–1821), military leader
This page lists people with the surname De Güemes.
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If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link.