Cefmenoxime

Cefmenoxime is a third-generation cephalosporin antibiotic.

Cefmenoxime

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Intramuscular, intravenous
ATC code	J01DD05 (WHO) S01AA31 (WHO), S02AA18 (WHO)
Pharmacokinetic data
Bioavailability	100% (given IM)
Protein binding	50% to 70%
Metabolism	Negligible
Elimination half-life	1 hour
Excretion	Kidney, unchanged
Identifiers
IUPAC name (6R,7R)-7-{[(2E)-2-(2-amino-1,3-thiazol-4-yl)- 2-methoxyimino-acetyl]amino}-3-[(1-methyltetrazol- 5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0] oct-2-ene-2-carboxylic acid
CAS Number	65085-01-0 Y
PubChem CID	9570757
DrugBank	DB00267 Y
ChemSpider	7845223 Y
UNII	KBZ4844CXN
KEGG	D07641 Y
ChEBI	CHEBI:55490 Y
ChEMBL	ChEMBL1201224 N
CompTox Dashboard (EPA)	DTXSID2022755
Chemical and physical data
Formula	C16H17N9O5S3
Molar mass	511.55 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)/c3nc(sc3)N)CSc4nnnn4C)C(=O)O
InChI InChI=1S/C16H17N9O5S3/c1-24-16(20-22-23-24)33-4-6-3-31-13-9(12(27)25(13)10(6)14(28)29)19-11(26)8(21-30-2)7-5-32-15(17)18-7/h5,9,13H,3-4H2,1-2H3,(H2,17,18)(H,19,26)(H,28,29)/b21-8-/t9-,13-/m1/s1 Y Key:HJJDBAOLQAWBMH-YCRCPZNHSA-N Y
NY (what is this?)  (verify)

External links

• Diseases Database (DDB): 30892
• Yokota N, Koguchi M, Suzuki Y, Fukayama S, Ishihara R, Deguchi K, Oda S, Tanaka S, Nakane Y, Fukumoto T (1995). "Antibacterial activities of cefmenoxime against recent fresh clinical isolates from patients in sinusitis". Jpn J Antibiot. 48 (5): 602–9. PMID 7637194.
• Paladino J, Fell R (1994). "Pharmacoeconomic analysis of cefmenoxime dual individualization in the treatment of nosocomial pneumonia". Ann Pharmacother. 28 (3): 384–9. doi:10.1177/106002809402800316. PMID 8193431. S2CID 29444681.
• Duncker G, Reich U, Krausse R (1994). "Cefmenoxime in corneal organ culture". Ophthalmologica. 208 (5): 262–6. doi:10.1159/000310505. PMID 7816419.