Glutamyl aminopeptidase (EC 3.4.11.7, aminopeptidase A, aspartate aminopeptidase, angiotensinase A, glutamyl peptidase, Ca2+-activated glutamate aminopeptidase, membrane aminopeptidase II, antigen BP-1/6C3 of mouse B lymphocytes, L-aspartate aminopeptidase, angiotensinase A2) is an enzyme encoded by the ENPEP gene. Glutamyl aminopeptidase has also recently been designated CD249 (cluster of differentiation 249).
| glutamyl aminopeptidase (aminopeptidase A) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ENPEP | ||||||
| Alt. symbols | gp160, CD249 | ||||||
| NCBI gene | 2028 | ||||||
| HGNC | 3355 | ||||||
| OMIM | 138297 | ||||||
| RefSeq | NM_001977 | ||||||
| UniProt | Q07075 | ||||||
| Other data | |||||||
| EC number | 3.4.11.7 | ||||||
| Locus | Chr. 4 q25 | ||||||
| |||||||
Glutamyl aminopeptidase is a zinc-dependent membrane-bound aminopeptidase that catalyzes the cleavage of glutamatic and aspartatic amino acid residues from the N-terminus of polypeptides. The enzyme degrades vasoconstricting angiotensin II into angiotensin III and therefore helps to regulate blood pressure.[1]
References
edit- ^ Reaux A, Iturrioz X, Vazeux G, Fournie-Zaluski MC, David C, Roques BP, Corvol P, Llorens-Cortes C (2000). "Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure". Biochem. Soc. Trans. 28 (4): 435–40. doi:10.1042/0300-5127:0280435. PMID 10961935.
External links
edit- The MEROPS online database for peptidases and their inhibitors: M01.003
- Glutamyl+aminopeptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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