CA45, CA-45, or CA 45 may refer to:
- California's 45th congressional district, a congressional district in the U.S. state of California
- California State Route 45, a state highway in California
- USS Wichita (CA-45), a United States Navy cruiser
- Calcium-45 (Ca-45 or 45Ca), an isotope of calcium
- Caproni Ca.45, an Italian aircraft
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