CA-38 may refer to:
- California's 38th congressional district, an electoral division in the State of California
- USS San Francisco (CA-38), a United States Navy New Orleans-class heavy cruiser
- California State Route 38, a highway in the State of California
- Calcium-38 (Ca-38 or 38Ca), an isotope of calcium
- Caproni Ca.38, an Italian aircraft
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