Brian Duffy may refer to:
- Brian Duffy (astronaut) (born 1953), American astronaut
- Brian Duffy (chef), celebrity chef
- Brian Duffy (photographer) (1933–2010), English photographer
- Brian John Duffy better known as Jet Black (1938–2022), drummer for The Stranglers
- Brian Duffy (actor), Scottish actor, writer, and artist
- Brian Duffy (weightlifter), New Zealand weightlifter
This disambiguation page lists articles about people with the same name.
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