Ask Me Anything may refer to:
- Ask Me Anything (film), 2014
- Ask Me Anything (album), 2015, by Jamie McDell
- "Ask Me Anything", a song by the Strokes on their album First Impressions of Earth
- Ask Me Anything (AMA), a common post topic in the /r/IAmA subreddit of Reddit
- Angela Scanlon's Ask Me Anything, an RTE programme in Ireland
- The prompt for a user to enter a question into Bing AI Bing Artificial Intelligence facility
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