William Appleton may refer to:
- William Appleton (politician) (1786–1862), congressman from Massachusetts
- Will Appleton (1889–1958), mayor of Wellington, New Zealand
- W. A. Appleton (William Archibald Appleton, 1859–1940), British trade union leader
- William Sumner Appleton (1874–1947), founder of the Society for the Preservation of New England Antiquities
- William M. Appleton (1920–2001), Pennsylvania politician
- William Henry Appleton (1814–1899), American publisher
- William Appleton (entrepreneur) (born 1961), American entrepreneur and technologist
- William H. Appleton (1843–1912), American soldier and Medal of Honor recipient
- William Thomas Appleton (1859–1930), Australian businessman, shipping agent and public servant
This disambiguation page lists articles about people with the same name.
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