Gary Keith Ackers (1939 - 2011)[1] was Emeritus Professor of Biochemistry and Molecular Biophysics of Washington University in St. Louis, Missouri.
Gary Keith Ackers | |
|---|---|
| Born | 1939 |
| Died | 2011 |
| Nationality | American |
| Known for | Agarose gel chromatography |
| Scientific career | |
| Fields | Thermodynamic linkage analysis of biological macromolecules, cooperative O2 binding to hemoglobin |
| Institutions | Washington University in St. Louis |
His research focused on thermodynamic linkage analysis of biological macromolecules, addressing the molecular mechanism of cooperative O2 binding to human hemoglobin since the early 1970s. He was a Fellow of the Biophysical Society and one of the founders of the annual Gibbs Conference.[2]
Professor Ackers invented agarose gel chromatography when he was a teenager. He went on the develop analytical gel chromatography methods for determinations of many important characteristics of water-soluble proteins; diffusion coefficient, molecular size, [3] [4] thermodynamics of protein-protein interactions including important changes due to single amino acid substitutions. [5]
References
edit- ^ "Obituary - Gary K. Ackers". Biophysical Society. August 2011. Retrieved 15 July 2013.
- ^ Gary Ackers Archived 2010-06-07 at the Wayback Machine faculty page at Washington University in St. Louis. Accessed on 2010-02-01.
- ^ Ackers GK (1967). "Molecular sieve studies of interacting protein systems. I. Equations for transport of associating systems". J. Biol. Chem. 242 (13): 3026–3034. doi:10.1016/S0021-9258(18)95928-4. PMID 6027787.
- ^ Ackers GK (1969). "Molecular sieve studies of interacting protein systems. IV. Molecular size of the D-amino acid oxidase apoenzyme subunit". J. Biol. Chem. 244 (2): 465–470. doi:10.1016/S0021-9258(18)94452-2. PMID 4388073.
- ^
Pettigrew DW, Romeo PH, Tsapis A, Thillet J, Smith ML, Turner BW, Ackers GK (1982). "Probing the energetics of proteins through structural perturbation: sites of regulatory energy in human hemoglobin". PNAS. 79 (6): 1849–1853. Bibcode:1982PNAS...79.1849P. doi:10.1073/pnas.79.6.1849. PMC 346078. PMID 6952235.
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