80 may refer to:
- 80 (number)
- one of the years 80 BC, AD 80, 1980, 2080
- B. B. King & Friends: 80, an album released in 2005
- 80 (Tolis Voskopoulos album), released in 1980
- "80", a song by Green Day from their 1991 album Kerplunk!
- 80 Sappho, a main-belt asteroid
- The Eighty (Vichy France), French parliamentarians who opposed the dissolution of the Third Republic