8-Hydroxyguanosine

8-Hydroxyguanosine
Names
	IUPAC name 2-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-3,7-dihydropurine-6,8-dione
	Other names 8-Oxoguanosine
Identifiers
CAS Number	3868-31-3 ;
3D model (JSmol)	Interactive image; Interactive image;
ChEMBL	ChEMBL1688964 ;
ChemSpider	228049 ;
ECHA InfoCard	100.162.784
PubChem CID	65131;
CompTox Dashboard (EPA)	DTXSID50959514 ;
	InChI InChI=1S/C10H13N5O6/c11-9-13-6-3(7(19)14-9)12-10(20)15(6)8-5(18)4(17)2(1-16)21-8/h2,4-5,8,16-18H,1H2,(H,12,20)(H3,11,13,14,19) Key: FPGSEBKFEJEOSA-UHFFFAOYSA-N ; InChI=1/C10H13N5O6/c11-9-13-6-3(7(19)14-9)12-10(20)15(6)8-5(18)4(17)2(1-16)21-8/h2,4-5,8,16-18H,1H2,(H,12,20)(H3,11,13,14,19) Key: FPGSEBKFEJEOSA-UHFFFAOYAG;
	SMILES C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)NC2=O)O)O)O; O=C3/N=C(/N)NC\1=C3\NC(=O)N/1C2OC(C(O)C2O)CO;
Properties
Chemical formula	C10H13N5O6
Molar mass	299.24 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

8-Hydroxyguanosine is an RNA nucleoside which is an oxidative derivative of guanosine. Measurement of the levels of 8-hydroxyguanosine is used as a biomarker of oxidative stress causing RNA damage.^[1]

References edit

^ Cattley RC, Glover SE (1993). "Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to carcinogenesis and nuclear localization". Carcinogenesis. 14 (12): 2495–2499. doi:10.1093/carcin/14.12.2495. PMID 8269617.

This biochemistry article is a stub. You can help Wikipedia by expanding it.

[1] Cattley RC, Glover SE (1993). "Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to carcinogenesis and nuclear localization". Carcinogenesis. 14 (12): 2495–2499. doi:10.1093/carcin/14.12.2495. PMID 8269617.

[1]

8-Hydroxyguanosine

See also edit

References edit