3-methylquercetin 7-O-methyltransferase
In enzymology, a 3-methylquercetin 7-O-methyltransferase (EC 2.1.1.82) is an enzyme that catalyzes the chemical reaction
3-methylquercitin 7-O-methyltransferase | |||||||||
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Identifiers | |||||||||
EC no. | 2.1.1.82 | ||||||||
CAS no. | 96477-62-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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- S-adenosyl-L-methionine + 5,7,3',4'-tetrahydroxy-3-methoxyflavone S-adenosyl-L-homocysteine + 5,3',4'-trihydroxy-3,7-dimethoxyflavone
Thus, the two substrates of this enzyme are S-adenosyl methionine and 5,7,3',4'-tetrahydroxy-3-methoxyflavone (isorhamnetin), whereas its two products are S-adenosylhomocysteine and 5,3',4'-trihydroxy-3,7-dimethoxyflavone (rhamnazin).
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase. Other names in common use include flavonol 7-O-methyltransferase, flavonol 7-methyltransferase, 7-OMT, S-adenosyl-L-methionine:3',4',5,7-tetrahydroxy-3-methoxyflavone, 7-O-methyltransferase, and 3-methylquercitin 7-O-methyltransferase [mis-spelt].
The enzyme can be found in Chrysosplenium americanum (American Golden Saxifrage).
References
edit- De Luca V, Ibrahim RK (1985). "Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. I. Partial purification and some properties of S-adenosyl-L-methionine:flavonol 3-, 6-, 7-, and 4'-O-methyltransferases". Arch. Biochem. Biophys. 238 (2): 596–605. doi:10.1016/0003-9861(85)90205-X. PMID 3994393.