Gepefrine, also known as 3-hydroxyamphetamine or α-methyl-meta-tyramine and sold under the brand names Pressionorm and Wintonin, is a sympathomimetic medication used as an antihypotensive agent which has been marketed in Germany.[1][2][3][4]
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Trade names | Pressionorm, Wintonin |
Other names | 3-Hydroxyamphetamine; meta-Hydroxyamphetamine; α-Methyl-meta-tyramine; 3-Hydroxy-α-methylphenethylamine |
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ECHA InfoCard | 100.012.779 |
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Formula | C9H13NO |
Molar mass | 151.209 g·mol−1 |
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Pharmacology
editGepefrine is described as a sympathomimetic and antihypotensive agent.[5]
Chemistry
editGepefrine, also known as 3-hydroxy-α-methylphenethylamine or as 3-hydroxyamphetamine, is a substituted phenethylamine and amphetamine derivative.[5] It is used pharmaceutically as the (S)-enantiomer and as the tartrate salt.[5][1] Related compounds include meta-tyramine (3-hydroxyphenethylamine), 4-hydroxyamphetamine (norpholedrine), 3,4-dihydroxyamphetamine (α-methyldopamine), and metaraminol ((1R,2S)-3,β-dihydroxyamphetamine), among others.
History
editGepefrine was synthesized by 1968[5] and was introduced for medical use in Germany by 1981.[3]
Society and culture
editNames
editGepefrine is the generic name of the drug and its INN .[5] Brand names of gepefrine include Pressionorm and Wintonin.[1][6]
Other drugs
editGepefrine is a known metabolite of amphetamine in rats.[4]
References
edit- ^ a b c Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 487. ISBN 978-3-88763-075-1. Retrieved 24 April 2012.
- ^ Macdonald F (1997). Dictionary of Pharmacological Agents. CRC Press. p. 127. ISBN 978-0-412-46630-4. Retrieved 24 April 2012.
- ^ a b Publishing, W.A.W.A. (2013). Pharmaceutical Manufacturing Encyclopedia. Volumes 1-4. Elsevier Science. p. 1760. ISBN 978-0-8155-1856-3. Retrieved 2024-09-01.
- ^ a b Jonsson J (October 1977). "Identification of metahydroxyamphetamine as a metabolite of amphetamine in the rat". Research Communications in Chemical Pathology and Pharmacology. 18 (2): 189–199. PMID 918344.
- ^ a b c d e Elks, J. (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. pp. 73–74. ISBN 978-1-4757-2085-3. Retrieved 2024-09-01.
- ^ Challener, C.A. (2017). Chiral Drugs. Routledge Revivals. Taylor & Francis. p. 552. ISBN 978-1-351-80804-0. Retrieved 1 September 2024.